Journal: Molecular Biology and Evolution
Article Title: Crohn's Disease and Genetic Hitchhiking at IBD5
doi: 10.1093/molbev/msr151
Figure Lengend Snippet: Geographic distribution of (A) the age of early Neolithic archaeological sites and (B) the 503F allele of OCTN1. The contour map in (A) is similar to figure 1A in Balaresque et al. (2010) and is based on the dates of 774 archaeological sites provided in Hassan (1985) and Pinhasi et al. (2005). The contour map in (B) is based on the population frequency of 503F in 85 populations across the Old World (supplementary table S2, Supplementary Material online). The intensity surfaces for the contour maps were generated using bicubic spline interpolation (Matlab r2009a griddata, 'v4' option), followed by truncation of values to fit the ranges indicated in the legends (r2009a). In (B), allele frequencies were averaged for populations located within 1°, and values were not interpolated for regions further than 10° from the nearest frequency data point (gray areas). The allele frequency of 503F in a population and the distance of that population to the nearest early Neolithic site are highly correlated (r2 = 0.44, P = 0.0067, t-test of Spearman’s ρ).
Article Snippet: The intensity surfaces for the contour maps were generated using bicubic spline interpolation (Matlab r2009a griddata, 'v4' option), followed by truncation of values to fit the ranges indicated in the legends (r2009a).
Techniques: Generated